Endocrine Disruptors

19 - 20 September 2022 - Frankfurt und online

Wir befinden uns in den Vorbereitungen für diese Veranstaltung, Details zur Agenda planen wir ca. drei Monate vor der Durchführung zu veröffentlichen. Wenn Sie Interesse an einem Thema haben, freuen wir uns über Ihren Input: anika.klinger@chem-academy.com

Zur Illustration des Themenspektrums finden Sie hier die Agenda der zuletzt durchgeführten Veranstaltung.

Monday, 1st March 2021

Registration and Coffee

Opening Remarks
Dr Bjoern Nehls, Director, Chem-Academy, and
Dr Volker J. Soballa, Vice President, Head of Product Stewardship,
Corporate ESHQ, Evonik Industries AG

Regulation of Endocrine Disruptors: Challenges for the Industry

  • Criteria and identification of Endocrine Disruptors
  • Harmonized European approach on ED under the Green deal (CLP, data requirements)
  • Industrial chemicals, biocides, plant protection products:
  • current issues from the industry’s point of view
  • The ECHA/EFSA Guidance and how to develop from that a horizontal one

Ellen Dhein, Director Environmental Policy, Bayer AG, Germany

Coffee Break

Test Methods and ED Identification

  • Progress in the FREIA project as part of the EURION cluster
  • Linking biomarkers to female reproductive toxicity and test methods for measuring
  • Indicators for reducing the need for test animals in the future
  • Possible pathways to explain how EDs can cause female reproductive disorders
  • Test methods to predict a chemical’s effect on female reproductive health
  • Test methods to identify human-made chemicals that disturb hormones

Prof Dr Majorie van Duursen, Faculty of Science, E&H: Environmental Health and Toxicology, Vrije Universiteit Amsterdam, The Netherlands

Assessment of Endocrine Disruption in Ecotoxicology – an Update on EU Developments

  • Regulatory context (ED guidance and regulation)
  • OECD framework and guidance
  • Tests for activity and adversity
  • Data interpretation and difficulties

Prof Dr Lennart Weltje, Senior Regulatory Scientist, BASF SE, Germany

Lunch Break

Assessment of EDs in the Biocides Sector

  • Criteria of Endocrine Disruptors and ECHA’s ED Guidance
  • From scientific information and regulatory data to measures of the authorities
  • Assessment on human health: conclusions so far
  • How ECHA’s ED Expert Group works
  • Product and product family:
  • assessing Endocrine Disruptors in Biocidal Products

Sander van der Linden, PhD, Scientific Officer, European Chemicals Agency (ECHA), Finland

The ECHA/EFSA Guidance for the Hazard Identification of Endocrine Disruptors in the Context of Regulation 1107/2009

  • Current test methods and knowledge for the identification on ED in non-target vertebrates
  • Challenges in the hazard identification of ED for non-target vertebrates
  • Available test methods and knowledge gaps for invertebrates
  • Available test methods and knowledge gaps for non-EATS modalities in non-target organisms

Maria Arena, Scientific Officer, European Food Safety Authority (EFSA)

Coffee Break

Weight of Evidence for Mechanistic Data including ED

  • The objectives and nature of Weight of Evidence (WOE) considerations for mechanistic data
  • Evolution of WOE in Mode of Action and Adverse Outcome Pathway Analysis
  • Integration with systematic methods for data assimilation and assessment
  • Potential path forward

Bette Meek, Ph.D., Associate Director, Chemical Risk Assessment,
McLaughlin Centre for Risk Science, University of Ottawa, Canada

Endocrine Disruptors: Hazard and Risk from a US Perspective

  • Hazard vs risk: the US vs the EU’s approach
  • Endocrine pathways: efficient hazard identification of EDCs
  • Potency ad threshold effects
  • Synthetic EDs and natural EDs
  • Pesticides, biocides, industrial chemicals: impact on uses
  • Where is the US regulation heading?

Dr Christopher J. Borgert, President & Principal Scientist, Applied Pharmacology and Toxicology, Inc., USA

Chairman’s Closing Remarks

End of Day One

Tuesday, 2nd March 2021

Chairman’s Opening Remarks
Dr Volker J. Soballa, Head of Product Stewardship, Corporate ESHQ,
Evonik Industries AG

Recent Experiences and Challenges With the ECHA/EFSA ED Guidance:
EU vs. Global Requirements

  • Requirements of the ED Guidance, challenges and related workload
  • Testing vs non-testing – “sufficiently investigated?” and first experiences
  • Regulatory view on potential Endocrine Disruptors worldwide:
  • Europe vs the Americas and Asia
  • Recommendations for dealing with ED assessments on a global scale

Dr Daniela Fruth, Ecotoxicology/Regulatory Affairs, Industrial Chemicals & Biocides, knoell Germany GmbH, Germany

Japanese Approach to Endocrine Disrupting Effects of Chemicals:

  • Outline of the Japanese programme on endocrine disrupting effects of chemicals: EXTEND2016
  • Testing and assessment under EXTEND2016
  • Bilateral collaboration and contribution to OECD Test Guidelines Programme
  • Path forward to regulatory environmental risk assessment
  • Environmental risk assessment under Japanese Chemical Substances Control Law

Dr Kunihiko Yamazaki, Environmental Health Department,
Ministry of Environment (MOE) Japan, Japan

Coffee Break

Breaking Down the Wall Between Human Health and Environmental Testing

  • The ERGO project as part of the EURION cluster
  • Aiming at a new approach for identifying endocrine effects
  • Key questions on thyroid hormone disruption
  • Endocrine Disruption and AOPs: current research and understanding
  • What does ecotox tell us about human toxicology?
  • And what does it not tell?

Prof Dries Knapen, Associate Professor, Department of Veterinary Sciences, University of Antwerp

State of the Research on Metabolic Effects of ED Chemicals

  • Objectives and framework of the EDCMET project
  • EDCMET and the EURION cluster
  • Adverse effects of metabolism disrupting chemicals
  • Development of validated test methods to assess metabolic effects of EDs
  • Identifying molecular initiating events linked to adverse outcomes
  • Highlights of research results

Jenni Küblbeck, PhD, Project Researcher, Scientific manager | EDCMET, University of Eastern Finland, AIV Institute for Molecular Sciences, Finland

Lunch Break

Applying the ED Criteria to Pesticides and Implications for Other Chemical Sectors

  • Applying ED criteria to pesticides: state of play
  • EU vs rest of the world
  • Challenges with implementation
  • The problem with lists
  • EU Chemicals Strategy for Sustainability: extending the criteria (and Guidance?) to less data rich chemical sectors?

Dr Andy Adams, Global Issue Management lead – Insecticides, Bayer S.A.S., France

Endocrine Disruptors and Health Risks – the Epidemiology’s Perspective

  • Epidemiological trends: health and quality of life
  • Endocrine modulation in human biology
  • Endocrine Disruption: the point of view of medical science(s)
  • Which kind of tox data is required?
  • The role of risk perception for health

Dr Alfred Pauls, Senior Consultant, ZEG Berlin, Germany

Coffee Break

Increasing the Robustness and Transparency of Regulatory Decisions in the
Face of the Uncertainties

  • The need for a plurality of scientific perspectives, taking endocrine disruptor evaluation as an example
  • Distinction between the different types of uncertainties we have to deal with: technical, methodological, epistemic and societal uncertainties and how a difference in tolerance of risk and
  • uncertainty can feed into scientific controversies.
  • Case description: scientific debate around Endocrine Disruptor evaluation
  • Discussion of methods, processes and tools we could apply on the path to good regulatory answers

Annegaaike Leopold, Consultant at Calidris Environment BV, The Netherlands, and
Adjunct Professor, Institute of Resources, Environment and Sustainability (IRES),
University of British Columbia, Canada

Chairman’s Closing Remarks

End of the Conference