Workshop

October 08 and 09, 2018 - Conference
October 10, 2018 - Workshop
Berlin, Germany

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Wednesday, 10th October 2018

8.30 Reception and Coffee

9.00 to 16.30 Weight of Evidence
Breaks will be arranged flexibly

Jim Bridges,
Emeritus Professor of Toxicology and Environmental Health, University of Surrey, Guildford, UK

Professor Bridges is the Emeritus Professor of Toxicology and Environmental Health at the University of Surrey, UK. Previously he held at various times the posts of: Dean for International Strategy, Dean of Science, Head of the European Institute of Health and Medical Sciences, Director of the Robens Institute of Industrial and Environmental Health. Previously he was a Lecturer in Biochemistry at St Mary’s Hospital Medical School, London University. For more than four decades Jim Bridges has been a member of various UK and international scientific advisory committees to governments and their agencies. The work of these committees has included: human and veterinary drugs, medical devices, biocides, industrial chemicals, nanomaterials, environmental contaminants, food additives and food residues, building materials, additives in consumer products and personal care products. He also chaired the EU DG SANCO scientific advisory committees CSTEE, SCHENIHR and their working groups on risk assessment methodology.
Professor Bridges is the author or joint author of over 400 research papers, reviews, and abstracts. He was a founder of the British Toxicology Society, EUROTOX and of the European Drug Metabolism Workshops. His main current research interest is in the development of quantitative weight of evidence for risk assessment purposes.

Target Group and Content of the Workshop
The workshop aims to empower participants in Weight of Evidence analysis. The key part of the workshop consists of four steps in order to understand how to make use of WoE in decision making.
I. Identifying the issue to be assessed, the types of data required for this and how to access them
2. Devising the scoring scheme for quality for each data type (study), e.g. in vivo, in vitro, in silico, considering both hazard and exposure aspects
3. Devising the scoring scheme for relevance for each type of study endpoints and the relative weighting to be given to each type, again including both hazard and exposure aspects
4. Conducting the Quality Weight of Evidence, identifying the uncertainties involved, and summing up for presenting conclusions/recommendations for the management.

Agenda
I. Framework for the application WoE
• Weight of Evidence: Different understandings of its definition and its application. Issues of    consistency, objectivity and transparency
• The relationship between the purpose of the risk assessment and the way it is conducted
• A general algorithm for conducting a QWoE
• Selecting the different sources of information on potential Endocrine Disruptors
• Consideration of different types of effects and the criteria for adverse vs adaptive
• Consideration of different types of study of exposure and their suitability

2. Conducting a QWoE Methodology: adverse effects
• Identification of the issues for the chemical(s) of concern:
• Steps in a quantitative WoE risk assessment methodology for adverse effects
• Common pitfalls when identifying best practices
• Evaluating the relative contribution of new methodologies
• Parameters to develop scoring for quality and relevance of studies to be assessed
   -Human
   -Animal
   -In vitro
   -Other, e.g. in silico

3. Identifying and Assessing the Risks
• Weighing the evidence for different sources for exposure
• Weighing the evidence for different sources for relevance
• Identifying and quantifying uncertainties
• Assessing ED related risks and value of worst case findings
• Setting the findings in context (sources, routes of exposure, normal variations related chemicals, benefits, etc

 

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